✦ LIBER ✦
Effects of salt loading on the fractional volume of atria-specific granules in dahl salt-sensitive and salt-resistant rats
✍ Scribed by Hansen, John T. ;Haywood, J. R. ;Howell, Andrew
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 706 KB
- Volume
- 218
- Category
- Article
- ISSN
- 0003-276X
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✦ Synopsis
The cardiac atria are known to play a role in blood volume homeostasis, secreting a peptide that induces a potent natriuresis and diuresis. This peptide is atrial natriuretic factor (ANF), and its primary site of storage is within atria-specific granules found in atrial cardiocytes.
Since salt loading results in an increase in circulating levels of ANF, our aim was to determine if the atria-specific granule population in the cardiocytes of Dahl rats would decrease accordingly. To this end, the fractional volume of the atria-specific