Effects of Roxarsone on Performance, Toxicity, Tissue Accumulation and Residue of Eggs and Excreta in Laying Hens

✍ Scribed by Chiou, Peter Wen-Shyg; Chen, Kuo-Lung; Yu, Bi

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 379 KB
• Volume: 74
• Category: Article
• ISSN: 0022-5142
• DOI: 10.1002/(sici)1097-0010(199706)74:2<229::aid-jsfa793>3.0.co;2-f

✦ Synopsis

In this study, we examined the e †ects of a high dosage of roxarsone in the diet on the performance, liver function, and its residue in liver, eggs and excreta of laying hens. Seventy-Ðve 32-week-old layers were selected and randomly allocated into Ðve dietary treatments with three replications for each treatment. Feeding periods were 4 weeks with an additional week for withdrawal. The experimental diets included 0, 11, 22, 44 or 88 mg kg~1 arsenic from roxarsone, respectively. Dietary arsenic above 44 mg kg~1 signiÐcantly decreased the egg production and feed intake of the layer (P \ 0É05). Layers ceased to produce eggs after two weeks of feeding the 88 mg kg~1 arsenic supplement diet. Where the enzyme activities in the serum, aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK) signiÐcantly increased. Also, the liver weight did not only signiÐcantly decrease (P \ 0É05), but was also damaged on histological examination. Moreover, arsenic residues in the liver, eggs and the excreta signiÐcantly increased as dietary arsenic level was increased (P \ 0É05). The serum enzyme activities of AST, LDH, CK returns to normal after a week of the drug withdrawal. Arsenic residues in liver, egg and excreta also signiÐcantly declined in the withdrawal period (P \ 0É05). Furthermore, the hepatic cells were vacuolised from layers treated with 88 mg kg~1 of arsenic.