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Effects of rivastigmine on motor and cognitive impairment in Huntington's disease

✍ Scribed by Marina de Tommaso; Nicola Specchio; Vittorio Sciruicchio; Olimpia Difruscolo; Luigi Maria Specchio

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 192 KB
Volume: 19
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20235

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

To evaluate the efficacy of rivastigmine on motor and cognitive impairment in Huntington's disease (HD), we carried out a prospective, open‐label, randomized, controlled study. Twenty‐one HD patients were enrolled: 14 were randomly sorted into medication and 7 to no‐treatment groups. Clinical and demographic features were similar between groups. After 8 months, an efficacy evaluation was carried out to compare the two groups. The improvement of cholinergic transmission in HD patients seemed to have a slight effect in ameliorating cognitive performance and slowing motor deterioration. © 2004 Movement Disorder Society

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