## Abstract **BACKGROUND:** __Dominant hemimelia (Dh)__ is an autosomal dominant mutation that arose spontaneously in mice. __Dh__ animals are asplenic and they exhibit asymmetric hindlimb defects in association with reduced numbers of lumbar vertebrae. These defects suggest that __Dh__ acts early
Effects of retinoic acid on embryonic development of mice in culture
β Scribed by T. Watanabe; R. M. Pratt
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 807 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1420-682X
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## Abstract Retinoic acid can cause malformations of the developing nervous system. Smad signaling is involved in embryonic development. The current study investigated allβ__transβ__retinoic acid (ATRA)βinduced alteration of Smad expression in the developing neural tubes of mice. Pregnant mice were