𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effects of repeated dose nitrazepam and lormetazepam on psychomotor performance in the elderly

✍ Scribed by Kevin Morgan

Publisher
Springer
Year
1985
Tongue
English
Weight
294 KB
Volume
86
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

The daytime psychomotor performance of 12 healthy subjects of mean age 81.4 years was examined in a double-blind crossover study following single and repeated nightly doses of nitrazepam 5 mg, lormetazepam 1 mg, and placebo. Accuracy of performance on the Gibson spiral maze was unaffected by both drugs. On a reciprocal tapping task, speed was similarly unaffected. However, while neither drug significantly impaired accuracy on reciprocal tapping after the first dose, nitrazepam, but not lormetazepam, significantly reduced overall accuracy after seven consecutive doses, an effect consistent with drug accumulation.

πŸ“œ SIMILAR VOLUMES

The effects of acute and repeated doses
The effects of acute and repeated doses of moclobemide on psychomotor performance and cognitive function in healthy elderly volunteers
✍ J. S. Kerr; D. B. Fairweather; I. Hindmarch πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 578 KB

The effects of moclobemide, a new selective and reversible MAO-A inhibitor, on cognitive function and psychomotor performance were measured in 12 healthy elderly male volunteers (with a mean age of 72.5 years). Subjects received moclobemide 200 mg, amitriptyline (positive internal control) 25 mg or

Residual effects of lormetazepam on mood
Residual effects of lormetazepam on mood and performance in healthy elderly volunteers
✍ J. B. Deijen; M. L. Heemstra; J. F. Orlebeke πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 548 KB

45 subjects aged over 65 years were randomly assigned to treatment with lormetazepam 0.5 mg or 1 mg or placebo. Mood and performance were measured with a battery of computerized tests. Subjects were tested before and after 1 and 8 nights of treatment. Pre- and post-treatment scores were analysed by

Alpidem: Lack of sedative effect on psyc
Alpidem: Lack of sedative effect on psychomotor performance in therapeutic doses
✍ P. Rosenzweig; S. Warrington; A. Patat; V. Ascalone; L. Bergougnan; P. L. Morsel πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 523 KB

This is a randomised, double blind, cross-over, placebo-controlled study carried out in 12 healthy young male volunteers. It consisted of six test days separated by two week wash-out periods. The objective was to compare the potential sedative effects of 3 single oral doses of alpidem (50 mg, 100 mg

Effects of temazepam on memory and psych
Effects of temazepam on memory and psychomotor performance: a dose–response study
✍ Alison Begg; Gordon Drummond; Brian Tiplady πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 68 KB πŸ‘ 1 views

In a randomised, three-period crossover study, psychomotor performance and memory were tested and mood assessed for 3 h after single doses of placebo (PL), 20 mg temazepam (T20) or 30 mg temazepam (T30) were given to six healthy females aged 21-23. A composite measure of psychomotor speed showed a d

The effects of repeated doses of clomipr
The effects of repeated doses of clomipramine and alprazolam on physiological, psychomotor and cognitive functions in normal subjects
✍ D. Allen; H. V. Curran; M. Lader πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 877 KB

The effects of a 10 day administration of clomipramine (25-50 mg t.i.d.), alprazolam (0.25-0.75 mg t.i.d.) and placebo were assessed in normal volunteers in a double-blind cross-over study. A battery of physiological, psychomotor and cognitive tests was administered both before and 3 h after drug on