Effects of repeated administration of the monoamine oxidase inhibitor phenelzine on the discriminability ofd-lysergic acid diethylamide (LSD) and 1-(m-trifluoromethylphenyl) piperazine (TFMPP)
✍ Scribed by Kathryn A. Cunningham; Brenda A. Carroll; James B. Appel
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 188 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0033-3158
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✦ Synopsis
Rats trained to discriminate d-lysergic acid diethylamide (LSD; 0.08 mg/kg) or 1-(m-trifluoromethylphenyl) piperazine (TFMPP; 0.8 mg/kg) were treated with the monoamine oxidase inhibitor (MAOI) phenelzine (10 rag/ kg/day) for 7 days. After a 24 h "washout" period, they were challenged with the training drug (and dose) or saline, during extinction test sessions. Following 0.08 mg/kg LSD, LSD-trained rats responded primarily on the saline lever (29% drug-appropriate responding) while, after TFMPP (0.8 mg/kg), TFMPP-trained animals responded on the drug lever (75% drug-appropriate responding). These preliminary data suggest that, if serotonin receptors are involved in the behavioral effects of TFMPP, these receptors differ from those involved in the effects of LSD.