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Effects of pyrogallol on O-methylation of dopamine and salsolinol

✍ Scribed by K. Iwasa; Y. Kondoh; M. Kamigauchi; D.U. Lee; U. Tanner; W. Wiegrebe


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
503 KB
Volume
38
Category
Article
ISSN
0031-9422

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(+)-(R)- and (-)-(S)-salsolinol, dopamine-derived tetrahydroisoquinolines, were tested as substrates of pig brain soluble and membrane-bound catechol-O-methyltransferase (COMT) and as inhibitors of O-methylation of dopamine by soluble COMT in vitro. Methylation products were separated by high-perfor