Effects of purified oil of Anguilla japonica on human plasma lipids and immune function

✍ Scribed by Shan Chun-Wen; Sun Li-Sha; Yang Su-Qin

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 229 KB
• Volume: 39
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/(sici)1098-2299(199610)39:2<135::aid-ddr4>3.0.co;2-q

✦ Synopsis

In hyperlipidemia rats fed the purified oil of Anguilla japonica (POAJ, 127.7-51 0.8 mglkg), we have shown that serum total cholesterol (TC), triglyceride (TG), and low density lipoprotein (LDL) decreasing percentages were 13.3-48.7,g.S-25.2, and 5.1-62.2%, respectively, high density lipoprotein (HDL) incrasing percentage was 8.2-67.3%, and the POAJ (255.4-51 0.8 mglkg) significantly reduced whole blood and plasma viscosity. The POAJ had marked increasing effect on some immunological indices, such as transferable function of T lymphocyte, in mice. In this paper, we show that the POAJ (1.8 g, 3 times a day, for 30 days) significantly lowered plasma lipids in 50 hyperlipidemia patients. The percentages of cases with marked efficiency for TC and TG decreasing were 92.0 and 88.0%, and those of cases with effectiveness (marked efficiency and efficiency) were 98.0 and 96.0%. In comparison with before-treatment values, the decreasing percentages of TC, TG, LDL, and VLDL levels were 28.6,54.3,27.3, and 50.0%, and the increasing percentage of HDL was 70.0%, At the same time, the POAJ dramatically changed some immunological indices in which IgG and IgM levels increased by 25.0 and 36.8%, but C4 levels were lowered by 33.3%, respectively. Drug Dev. Res. 393 35-1 37.