The effects of externally applied different protein kinase C (PKC) activators on Na+ currents in mouse neuroblastoma cells were studied using the perforated-patch (nystatin-based) whole cell voltage clamp technique. Two diacylglycerol-like compounds, OAG (1-oleoyl-2-acetyl-sn-glycerol), and DOG (1-2
Effects of protein kinase C activators on mouse skin in vivo
โ Scribed by S. Inohara; H. Tateishi; Y. Takeda; Y. Tanaka; S. Sagami
- Publisher
- Springer-Verlag
- Year
- 1988
- Tongue
- English
- Weight
- 864 KB
- Volume
- 280
- Category
- Article
- ISSN
- 0340-3696
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## Abstract The effect of protein kinase C (PKC) inhibitors on porcine oocyte activation by calcium ionophore A23187 was studied. Calcium ionophore applied in a 50 ยตM concentration for 10 min induced activation in 74% of oocytes matured in vitro. When the ionophoreโtreated oocytes were exposed to t
Protein kinase C (PKC) comprises a family of related phospholipid-dependent serine/threonine protein kinases. PKC is important in signal transduction, regulating cell proliferation and differentiation. Recently, it has also been suggested that PKC may play a part in the pathogenesis of contact derma