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Effects of pressure on the helix–coil transitions of the poly A–poly U system

✍ Scribed by F. Hughes; R. F. Steiner

Publisher
Wiley (John Wiley & Sons)
Year
1966
Tongue
English
Weight
591 KB
Volume
4
Category
Article
ISSN
0006-3525

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✦ Synopsis

Synopsis

Studies were made of the influence of hydrostatic pressure on the helix-coil transitions of poly(A + U) and poly(A + 2U). The results were analyzed by a thermodynamic treatment which emphasized the cooperative aspect of the transitions. The helix-to-coil volume changes were found to be small and negative indicating pressure stabilization of the coil form. The significance of the results with respect to other denaturation measuremenbs was discussed.

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