𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effects of postnatal ethanol exposure on neurotrophic factors and signal transduction pathways in rat brain

✍ Scribed by Vittorio Fattori; Shin-ichi Abe; Kumiko Kobayashi; Lucio G. Costa; Ryozo Tsuji

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
257 KB
Volume
28
Category
Article
ISSN
0260-437X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Exposure to ethanol during development induces severe brain damage, resulting in a number of CNS dysfunctions including microencephaly and mental retardation. Potential targets of ethanol‐induced neurotoxicity include neurotrophic factors and their signal transduction pathways. In the present study, rat pups were given ethanol at the dose of 5 g kg^−1^ via gavage from postnatal day (PND) 5 to 8, and mRNA expression of nerve growth‐factor (NGF), brain‐derived neurotrophic factor (BDNF), and neurotrophic factor‐3 (NT‐3) in the cerebral cortex was examined, with attention to signal transduction, on PND 8. The mRNA level of BDNF was decreased by ethanol while those of NGF or NT‐3 were not changed. Brain weights were decreased and the levels of phospho‐MAPK, phospho‐p70S6K and phospho Akt were decreased while phosphor‐PKC__ζ__ and phospho‐CREB remained unchanged. These results suggest that BDNF and its related signal pathways involving Akt, MAPK and p70S6K are potential targets of ethanol‐induced developmental neurotoxicity. Copyright © 2007 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Effects of escitalopram on the regulatio
Effects of escitalopram on the regulation of brain-derived neurotrophic factor and nerve growth factor protein levels in a rat model of chronic stress
✍ Olaf Schulte-Herbrüggen; Eberhard Fuchs; Nashat Abumaria; Annerose Ziegler; Heid 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 364 KB

## Abstract Escitalopram (ES‐CIT) is a widely used, highly specific antidepressant. Until now there has been very little evidence on how this drug under pathological conditions affects an important feature within the pathophysiology of stress‐related disorders such as depression: the endogenous neu

Effects of inhibitors of signal transduc
Effects of inhibitors of signal transduction pathways on transforming growth factor B1 and osteogenic protein-1-induced insulinlike growth factor binding protein-3 expression in human bone cells
✍ Narasimhan Srinivasan; David J. Baylink; Kuber Sampath; Subburaman Mohan 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 202 KB 👁 2 views

Signal transduction initiated by TGFb1 and OP-1 was studied in MG63 human osteosarcoma cells and in normal human bone cells (HBCs) in the presence of inhibitors of signal transduction events, using insulinlike growth factor binding protein-3 (IGFBP-3) production as an end point. Treatment of serum-f

Biphasic effects of chronic ethanol expo
Biphasic effects of chronic ethanol exposure on insulin-stimulated glucose uptake in primary cultured rat skeletal muscle cells: role of the Akt pathway and GLUT4
✍ Wei Qu; Lina Zhao; Xiaolin Peng; Xuefeng Yang; Chenjiang Ying; Liping Hao; Xiufa 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB 👁 1 views

## Abstract ## Background Mild or moderate chronic alcohol intake has been shown to be associated with increased insulin sensitivity, while chronic alcohol abuse demonstrates a contrary effect. The mechanism underlying this biphasic effect has not yet been clarified. We investigated whether chroni

Effects of retinoids on the production o
Effects of retinoids on the production of tumour necrosis factor-alpha and nitric oxide by lipopolysaccharide-stimulated rat Kupffer cells in vitro: evidence for participation of retinoid X receptor signalling pathway
✍ Kenta Motomura; Hironori Sakai; Hidehiko Isobe; Hajime Nawata 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 243 KB 👁 3 views

Kupffer cells play important roles in the development of liver injury by producing cytokines and free radicals. In consequence inhibition of these inflammatory mediators will be one of the targets for treating liver diseases. Retinoids modulate a wide variety of functions of monocytes/macrophages. C