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Effects of Polyamines, Polyamine Analogs, and Inhibitors of Protein Synthesis on Spermidine−Spermine N 1 -Acetyltransferase Gene Expression †

✍ Scribed by Fogel-Petrovic, Mirjana; Vujcic, Slavoljub; Brown, Patricia J.; Haddox, Mari K.; Porter, Carl W.


Book ID
127224184
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
361 KB
Volume
35
Category
Article
ISSN
0006-2960

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Spermidine/spermine N 1 -acetyltransferase (cSAT), a key enzyme in polyamine degradation, is induced by various hepatotoxins and liver tumor promoters. In this paper we demonstrate that physiological factors, such as cytokines, control cSAT expression in HepG2 human hepatocarcinoma cells. Hepatocyte