Effects of platelet derived growth factor, epidermal growth factor and transforming growth factor-β on the growth of human marrow fibroblasts
✍ Scribed by Akiro Kimura; Osamu Katoh; Atsushi Kuramoto
- Book ID
- 114711553
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 371 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0007-1048
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## Abstract Platelet‐derived growth factor (PDGF) and transforming growth factor β (TGF‐β), potent modulators of mesenchymal cell growth and differentiation, are often colocalizable in vivo. Previous in vitro studies in fibroblastic cell lines have shown variable, even antagonistic effects of TGF‐β
Anchorage-independent growth, i.e., growth in semi-solid medium is considered a marker of cellular transformation of fibroblast cells. Diploid human fibroblasts ordinarily do not exhibit such growth but can grow transiently when medium contains high concentrations of fetal bovine serum. This suggest