Effects of plasmapheresis on peripheral blood mononuclear cell populations from patients with macroglobulinemia

✍ Scribed by Teresa Paglieroni; Vincent Caggiano; Malcolm R. Mackenzie

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 597 KB
• Volume: 3
• Category: Article
• ISSN: 0733-2459
• DOI: 10.1002/jca.2920030403

✦ Synopsis

Effects of plasrnapheresis on peripheral blood T-cell. B-cell, monocyte, and natural-killer-cell populations were studied in ten macroglobulinemia patients with hyperviscosity syndrome. Following plasrnapheresis, there was a transient decrease in the number of T4+ helper cells and a longer-lasting decrease in the number of Leu-7+ natural killer cells and Mo2+ monocytes. In addition, there was a greater than 50% decrease in the in vitro ingestion capacity of monocytes. Although no significant changes in the numbers of IgM+, BI+, B4+, or PCA+ B cells (P > -05) were detected, there was a highly significant (P < .01) increase in 12 antigen density on the surface of IgM + B cells and in the bromodeoxyuridine uptake by these cells 7-9 days after plasmapheresis. These findings suggest that following plasrnapheresis, IgM + B cells are activated. Using flow cytonietry to determine when maximum IgM + B cell activation occurs by measuring I2 antigen density on the cell surface may be useful in determining the postplasmapheresis timing of chemotherapy in macroglobulinemia patients with hyperviscosity syndrome who require more aggressive treatment.