Effects of phorbol myristate acetate, phorbol dibutyrate, ethanol, dimethylsulfoxide, phenol, and seven metabolities of phenol on metabolic cooperation between chinese hamster v79 lung fibroblasts
✍ Scribed by A. Russell Malcolm; Lesley J. Mills; Edward J. McKenna
- Book ID
- 104627827
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 1013 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0742-2091
No coin nor oath required. For personal study only.
✦ Synopsis
support the hypothesis that tumor promoters inhibit metabolic cooperation and illustrate the importance of considering metabolites when testing this hypothesis. The weak capacity of five metabolites of phenol to inhibit metabolic cooperation correlates with the weakness of phenol as a tumor promoter. Interpretation of these results is complicated because two metabolic cooperation-inhibiting metabolites (catechol and quinol) are nonpromoting when tested individually in the same assay where phenol shows promoting activity. Such metabolites may be incomplete (stage)promoters, and exposure to two or more may be required for a promoting effect. The significance of enhanced metabolic cooperation requires further investigation, particularly in relation to antipromoting effects.