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Effects of phenytoin on the in vivo kinetics of thiamine and its phosphoesters in rat nervous tissues

โœ Scribed by Cesare Patrini; Emilio Perucca; Carlo Reggiani; Gianguido Rindi


Book ID
115804101
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
696 KB
Volume
628
Category
Article
ISSN
0006-8993

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The effects of ibuprofen on maternal phenytoin pharmacokinetics and fetal phenytoin acquisition were investigated in 19-day gestation Sprague-Dawley rats. A 5 mg kg-' bolus injection of I4C-phenytoin was given with and without (control) pretreatment with 12.5 mg kg-' of ibuprofen. Maternal plasma an