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Effects of phenylsuccinate on potassium-stimulated taurine release in cultured neurons and astrocytes and in rat hippocampus in vivo

✍ Scribed by Torben Bruhn; Thomas Christensen; Manuela Cobo; Inge Damgaard; Nils H. Diemer; Arne Schousboe

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 612 KB
Volume: 46
Category: Article
ISSN: 0360-4012
DOI: 10.1002/(sici)1097-4547(19961015)46:2<198::aid-jnr7>3.0.co;2-c

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✦ Synopsis

Swelling-induced release of taurine was investigated in vivo in hippocampus by microdialysis or in vitro in cultured neocortical neurons or astrocytes. Swelling was induced either by increasing the extracellular K + concentration or by exposing the cells to hyposmotic conditions. It was found that the drug phenylsuccinate, which inhibits the mitochondria1 dicarboxylate carrier as well as biosynthesis of neurotransmitter glutamate, inhibits swelling-induced taurine release both in vivo and in cultured cells. Thus, phenylsuccinate may be used to investigate the mechanism involved in taurine release associated with regulatory volume decrease in cells.

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