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Effects of pharmacological manipulations of cannabinoid receptors on severity of dystonia in a genetic model of paroxysmal dyskinesia

✍ Scribed by Angelika Richter; Wolfgang Löscher

Book ID
114015153
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
217 KB
Volume
454
Category
Article
ISSN
0014-2999

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✍ Maren Fedrowitz; Melanie Hamann; Jan H. Rehders; Angelika Richter; Manuela Gerne 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 185 KB

The dt(sz) hamster is a well-established animal model of idiopathic paroxysmal dystonia. Previous investigations of this mutant have indicated dysfunctions of the gamma-aminobutyric acid (GABA)-ergic system within the basal ganglia. Systemic administration of the central stimulant pentylenetetrazole