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Effects of pentamidine on QT interval and ether-a-go-go related gene expression in cynomolgus monkeys

✍ Scribed by Koichi Kuwano; Junko Matsuo; Shinya Ohkuma; Masaaki Ban; Akiko Suzuki; Takeshi Kamenosono; Takayuki Sukamoto; Koichiro Fukuzaki; Ryoichi Nagata

Book ID
113942184
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
54 KB
Volume
64
Category
Article
ISSN
1056-8719

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πŸ“œ SIMILAR VOLUMES

Effects of phosphodiesterase (PDE) inhib
Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity
✍ Kiyokazu Yunomae; Satoko Ichisaki; Junko Matsuo; Shinichi Nagayama; Koichiro Fuk πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 328 KB

## Abstract It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether‐a‐go‐go related gene (hERG) activities by PKA‐dependent pathway mediated phosphorylation