Effects of pantolactone and butyrolaectone on the pleiotropic phenotypes oflonmutants and on thermal induction of the SOS phenomena in atifmutant ofEscherichia coliK12

✍ Scribed by Hiroaki Nakayama; Koji Nakayama; Ritsuko Nakayama; Yasuhiko Kato

• Book ID: 104764256
• Publisher: Springer
• Year: 1982
• Tongue: English
• Weight: 554 KB
• Volume: 132
• Category: Article
• ISSN: 0302-8933
• DOI: 10.1007/bf00413380

✦ Synopsis

Pantolactone and butyrolactone, known to suppress cell filament formation in the lon mutant of Escherichia coli, were found also to be capable of partially correcting other anomalies of the mutant including impaired lysogenization with bacteriophages lambda and P1 and increased synthesis of colanic acid. In contrast to pantolactone, which inhibited thermal induction of cell filament formation and lambda prophage in the tifmutant as previously described, butyrolactone enhanced these phenomena. It was inferred that whereas these substances exert their effects through acting upon the tif-recA protein in the t/f bacterium, there is a distinct target for their characteristic actions in the Ion mutant.