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Effects of overfeeding on energy balance and brown fat thermogenesis in obese (ob/ob) mice

โœ Scribed by Trayhurn, Paul; Jones, Pauline M.; McGuckin, Martina M.; Goodbody, Anne E.

Book ID
109725371
Publisher
Nature Publishing Group
Year
1982
Tongue
English
Weight
409 KB
Volume
295
Category
Article
ISSN
0028-0836

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Effect of metformin on hepatocyte insuli
Effect of metformin on hepatocyte insulin receptor binding in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice
โœ J. M. Lord; T. W. Atkins; C. J. Bailey ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 575 KB

The effect of metformin on hepatocyte insulin receptor binding was examined in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice. In normal mice, chronic administration of metformin (60 mg X kg-1 X day-1 for 50 weeks) increased the number of low affinity receptors by 148%.