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Effects of (−)-OSU6162 and ACR16 on motor activity in rats, indicating a unique mechanism of dopaminergic stabilization

✍ Scribed by Johan P. Rung; Emilia Rung; Lisa Helgeson; Anette M. Johansson; Kjell Svensson; Arvid Carlsson; Maria L. Carlsson

Publisher
Springer
Year
2008
Tongue
English
Weight
379 KB
Volume
115
Category
Article
ISSN
1435-1463

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Effects of the substituted (S)-3-phenylpiperidine (−)-OSU6162 on PET measurements in subhuman primates: Evidence for tone-dependent normalization of striatal dopaminergic activity
✍ J. Tedroff; R. Torstenson; P. Hartvig; C. Sonesson; N. Waters; A. Carlsson; H. N 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB 👁 3 views

Ϫ)-OSU6162 is a substituted (S)-3-phenylpiperidine derivative which exhibits some affinity to the dopamine D 2 receptor family. In vivo, the compound displays a unique normalizing profile on psychomotor activity by an intriguing mixture of stimulatory and inhibitory properties. In the present invest