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Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healing

โœ Scribed by Eleftherios Tsiridis; Elise F. Morgan; Jared M. Bancroft; Mike Song; Michael Kain; Louis Gerstenfeld; Thomas A. Einhorn; Mary L. Bouxsein; Paul Tornetta III

Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
555 KB
Volume
25
Category
Article
ISSN
0736-0266

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โœฆ Synopsis

Abstract

The purpose of this study was to establish a reliable model of metaphyseal bone healing and to use this model to investigate the effect of recombinant human osteogenic protein 1 (rhOPโ€1; BMPโ€7) and parathyroid hormone fragment (PTH 1โ€“34) on healing. A wedgeโ€shaped osteotomy was created in the distal tibia of 16โ€weekโ€old female New Zealand White rabbits (nโ€‰=โ€‰20) and was bridged with a customโ€made external fixator. Five experimental groups of four animals each were investigated. In groups 1โ€“4 the osteotomy gap was filled with tricalcium phosphate (TCP), and the gap was left unfilled in group 5 (โ€œnormal healingโ€). In group 1, 200 ยตg OPโ€1 was mixed in with the TCP. Groups 2 and 3 received daily subcutaneous injections of 10 and 40 ยตg/kg PTH, respectively, beginning on postoperative day 1. Radiographs were taken weekly. Following sacrifice on postoperative day 28, peripheral quantitative computed tomography (pQCT), histology, and mechanical testing (axial compression and torsion) were performed. Only one animal failed to complete the full 4โ€week time course, and no infections were encountered. Bone healing occurred in all animals. OPโ€1 stimulated bone formation locally, while the lower dose of PTH enhanced bone formation systemically (pโ€‰<โ€‰0.05). Tibiae treated with OPโ€1 exhibited higher torsional strength (pโ€‰=โ€‰0.04) than those in the normal healing group. These results indicate that a reliable and reproducible surgical model of metaphyseal healing has been established. In addition, differences in systemic versus local effects of PTH and OPโ€1 in accelerating metaphyseal fracture healing were found. ยฉ 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1193โ€“1203, 2007

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