Effects of ochratoxins A and B on prechondrogenic mesenchymal cells from chick embryo limb buds
✍ Scribed by Wiger, Richard; Størnier, Fredrik C.
- Book ID
- 122988557
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 490 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0378-4274
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In the presence of 4 mM inorganic phosphate, differentiating chick limb-bud mesenchymal cells plated in micromass cultures form a mineralized matrix resembling that of chick calcified cartilage. To test the hypothesis that cartilage proteoglycans are inhibitors of cell mediated mineralization, the s
## Abstract Endochondral ossification is initiated by differentiation of mesenchymal cells into chondrocytes, which produce a cartilaginous matrix, proliferate, mature, and undergo hypertrophy, followed by matrix calcification, and substitution of cartilage by bone. A number of hormones and growth