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Effects of nimesulide and its metabolites or manufacturing intermediates on the viability and growth of the human hepatoma HepG2 cell line

✍ Scribed by K.D. Rainsford; R.W. Seabrook; S. Spencer; A.T. Hewson

Book ID: 117173264
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 416 KB
Volume: 69
Category: Article
ISSN: 0024-3205
DOI: 10.1016/s0024-3205(01)01405-9

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## Abstract Primary cultures of human hepatocytes and hepatoma cell line HepG2 are frequently used to evaluate the hepatic disposition of drugs and other xenobiotics. To check the variability of the expression of drug‐metabolizing enzymes in these in vitro models, expression of genes coding for sev