Effects of nefiracetam, a novel pyrrolidone derivative, on brain monoamine metabolisms in mice
β Scribed by E. Abe; S. Murai; H. Saito; Y. Masuda; T. Itoh
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 824 KB
- Volume
- 90
- Category
- Article
- ISSN
- 1435-1463
No coin nor oath required. For personal study only.
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## Abstract The effect of a lack of the gene encoding monoamine oxidase A (MAO A) in transgenic Tg8 mice on the activity of tryptophan hydroxylase (TPH), the rateβlimiting enzyme in serotonin (5βHT) biosynthesis, and on the levels of 5βHT and 5βhydroxyindoleacetic acid (5βHIAA) in the midbrain, hyp
Levels of monoamine metabolites in three different regions of the rat brain were determined following treatment with piracetam (0.5 and 5g/kg, i.p.). The concentration of prolactin in serum was also measured. Piracetam, at 5 g/kg, increased the levels of dihydroxyphenylacetic acid, homovanillic aci