We have tested the hypothesis that dense cell formation in sickle cell disease is associated with increased binding of calpromotin to the membrane, an event that occurs during the activation of calcium-dependent potassium transport. By SDS polyacrylamide gel electrophoresis, we found that sickle cel
Effects of N-acetylcysteine on dense cell formation in sickle cell disease
β Scribed by Betty S. Pace; Archil Shartava; Ardie Pack-Mabien; Mudhari Mulekar; Alfredo Ardia; Steven R. Goodman
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 134 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0361-8609
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## Abstract Sickle cell disease (SCD) is a class of hemoglobinopathy in humans, which causes a disruption of the normal activities in different systems. Although this disease begins with the polymerization of red blood cells during its deoxygenating phase, it can erupt into a cascade of debilitatin
## Abstract An increase in plasma ammonia level in human volunteers on restricted zinc intake, and in zincβdeficient rats, has recently been reported. Inasmuch as zinc deficiency has been observed in sickle cell anemia patients, we measured plasma ammonia levels in such subjects. In this report we