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Effects of modulators of myosin light-chain kinase activity in single smooth muscle cells

✍ Scribed by Itoh, Takeo; Ikebe, Mitsuo; Kargacin, Gary J.; Hartshorne, David J.; Kemp, Bruce E.; Fay, Fredric S.

Book ID
109758186
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
441 KB
Volume
338
Category
Article
ISSN
0028-0836

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Effects of a myosin light chain kinase inhibitor, wortmannin, on cytoplasmic Ca2+levels, myosin light chain phosphorylation and force in vascular smooth muscle
✍ Makoto Takayama; Hiroshi Ozaki; Hideaki Karaki πŸ“‚ Article πŸ“… 1996 πŸ› Springer-Verlag 🌐 English βš– 870 KB

Biochemical studies have shown that wortmannin is an inhibitor of myosin light chain (MLC) kinase (Nakanishi et al. (1992) J. Biol. Chem. 267: 2157-2163). To investigate the role of MLC kinase in smooth muscle contractions, we examined the effects of wortmannin on isolated smooth muscles of the rat