Effects of mexiletine, ginkgo biloba extract (EGb 761), and their combination on experimental head injury
✍ Scribed by Ahmet Menkü; R.Kemal Koç; Vatan Tayfur; Recep Saraymen; Figen Narin; Hidayet Akdemir
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 110 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0344-5607
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Primary cultures of rat hippocampal neurons were prepared and exposed to increasing concentrations of a peroxyl radical-generator, 2,2′-azobis 2 amidinopropane (AAPH). Addition of AAPH (20 or 50 mM) to the medium caused a decrease in cell viability and an increase in the number of apoptotic cells. V
The metabolic action of an extract of Ginkgo biloba (EGb 761) has been examined in an ex vivo study of rat erythrocytes. Oral administration of EGb 761 (100 mg/kg/day) for 5 days to Wistar rats caused an increase in the in vitro uptake of glucose by erythrocytes, especially in high-glucose (13.32 mM
The effects of repeated (15-day) oral treatments with an extract of Ginkgo biloba (EGb 761; 50 mg/kg/day) or with its terpenoid constituent, bilobalide (2 mg/kg/day), were assessed in normal rats and in rats that had been previously injected with streptozotocin (50 mg/kg, i.p. in saline solution), a