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Effects of mevinolin and mevalonate on cell growth in several transformed cell lines

✍ Scribed by Kathy P. Fairbanks; Veronique D. Barbu; Larry D. Witte; I. Bernard Weinstein; DeWitt S. Goodman

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
836 KB
Volume
127
Category
Article
ISSN
0021-9541

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✦ Synopsis

Studies were conducted to explore the effects of mevinolin, a competitive inhibitor of HMG CoA reductase, on the growth and morphology of normal and transformed murine fibroblasts. Mevinolin is known to block DNA synthesis and cell growth in a n u m b e r of kinds of non-transformed cells. Eight cell lines were studied, including two normal fibroblast cell lines (C3H 10T 112 and NIH 3T3) and derivatives of these cell lines transformed by chemical carcinogens, X-irradiation or the H-ras oncogene. All of the eight cell lines displayed appreciable growth inhibition by 5 pM mevinolin and marked inhibition by 30 pM mevinolin. Mevinolin also induced a marked rounding in the morphology of all of t h e cell lines. These effects of mevinolin on cell

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