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Effects of medial septal or unilateral hippocampal inactivations on reference and working spatial memory in rats

โœ Scribed by B. Poucet; M.-C. Buhot

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
765 KB
Volume
4
Category
Article
ISSN
1050-9631

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โœฆ Synopsis

Abstract

The memory performances of rats receiving a reversible inactivation of either the medial septum or one side of the ventral hippocampus were compared in a radial arm maze task allowing the assessment of both working and reference memory. After preโ€surgery training, rats were chronically equipped with bilateral cannulae into the ventral hippocampus and a single cannula into the medial septum. Following postโ€surgery retraining, animals received a series of test trials during which they received saline or lidocaine injections in either the medial septum or one side of the ventral hippocampus. Lidocaine injections in either structure resulted in both reference and working memory deficits. However, animals were more impaired after septal injections than after unilateral hippocampal injections. This result suggests that the septoโ€hippocampal formation acts as a functionally homogeneous structure essential for spatial processing. ยฉ 1994 Wileyโ€Liss, Inc.

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