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Effects of MDMA and related analogs on plasma 5-HT: Relevance to 5-HT transporters in blood and brain

✍ Scribed by Samanta Yubero-Lahoz; Mario A. Ayestas Jr.; Bruce E. Blough; John S. Partilla; Richard B. Rothman; Rafael de la Torre; Michael H. Baumann


Book ID
113589686
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
769 KB
Volume
674
Category
Article
ISSN
0014-2999

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There is consistent preclinical evidence that brain 5-HT and 5-HIAA concentrations are abnormal during natural ageing (Kabuto et al., 1995). Furthermore, plasma/CSF 5-HT and 5-HIAA concentrations are reduced in both vascular and Alzheimer's type dementia, which may be due to abnormal progressive cel