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Effects of Lower Concentration Thrombin on High-Mobility Group Box 1 Protein-Mediated Inflammatory Responses

✍ Scribed by Jong-Sup Bae

Book ID
113067030
Publisher
Springer
Year
2011
Tongue
English
Weight
358 KB
Volume
35
Category
Article
ISSN
0360-3997

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✍ Sanghyun Lee; Hojung Song; Hyun Ah Kim; Binna Oh; Dong Yun Lee; Minhyung Lee 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 445 KB

## Abstract High mobility group box‐1 (HMGB‐1) is a DNA binding nuclear protein and pro‐inflammatory cytokine. The box A domain of HMGB‐1 (rHMGB‐1A) exerts an anti‐inflammatory effect, inhibiting wild‐type HMGB‐1 (wtHMGB‐1). In this study, HMGB‐1A was evaluated as an siRNA carrier with anti‐inflamm