Mice with the deleted neurofilament of l
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M. Dubois; R. Lalonde; J.-P. Julien; C. Strazielle
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Article
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2005
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John Wiley and Sons
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English
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Neuronal intermediate filaments consist of the NFL subunit linked with NFM and NFH, and their alterations have been proposed as a pathogenesic cause in motor neuron diseases. Depletion of the Nefl gene in mice mimicks the reduced NFL mRNA levels seen in amyotrophic lateral sclerosis and causes perik