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Effects of low doses of glycosaminoglycans and insulin-like growth factor-I on motor neuron disease in wobbler mouse

✍ Scribed by Letizia Vergani; Cristina Finco; Anna Maria Di Giulio; E.E Muller; Alfredo Gorio


Book ID
117475474
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
186 KB
Volume
228
Category
Article
ISSN
0304-3940

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We investigated the histological effects of ciliary neurotrophic factor on degenerating motor neurons, their axons, and skeletal muscles in 68 wobbler mice with motor neuron disease. Treatment consisted of recombinant rat or human ciliary neurotrophic factor (or a vehicle solution), 1-mg/kg subcutan