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Effects of lovastatin on the pharmacokinetics of verapamil and its active metabolite, norverapamil in rats: Possible role of P-glycoprotein inhibition by lovastatin

โœ Scribed by Soon-Pyo Hong; Kyoung-Sig Chang; Young-Youp Koh; Dong-Hyun Choi; Jun-Shik Choi


Book ID
107642142
Publisher
Springer
Year
2009
Tongue
English
Weight
208 KB
Volume
32
Category
Article
ISSN
0253-6269

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Effects of naringin on the pharmacokinet
โœ Hyoung J. Kim; Jun S. Choi ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 95 KB ๐Ÿ‘ 2 views

It was reported that verapamil is metabolized via hepatic microsomal cytochrome P450 (CYP) 3A4 and that naringin (a component of grapefruit juice) inhibits CYP3A4 in humans. Hence, after oral administration of verapamil, the total area under the plasma concentration-time curve from time zero to time