Effects of lovastatin on adenylyl cyclase activity and G proteins in GH4C1 cells
✍ Scribed by Antonio Chiloeches; Marina Lasa; Fuensanta Brihuega; Agustín Montes; María J. Toro
- Book ID
- 115930534
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 477 KB
- Volume
- 361
- Category
- Article
- ISSN
- 0014-5793
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Parathyroid hormone (PTH) sensitive adenylyl cyclase activity (ACA) in SaOS-2 cells varies as a function of cell passage. In early passage (EP) cells (< 6), ACA in response to PTH and forskolin (FOR) was relatively low and equivalent, whereas in late passage (LP) cells (> 22), PTH exceeded FOR depen
Heterotrimeric G-proteins, composed of alpha and betagamma subunits, transmit signals from cell-surface receptors to cellular effectors and ion channels. Cellular responses to receptor agonists depend on not only the type and amount of G-protein subunits expressed but also the ratio of alpha and bet