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Effects of lorazepam on memory, attention and sedation in man

✍ Scribed by G. C. Preston; P. Broks; M. Traub; C. Ward; P. Poppleton; S. M. Stahl

Publisher: Springer
Year: 1988
Tongue: English
Weight: 858 KB
Volume: 95
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00174511

No coin nor oath required. For personal study only.

✦ Synopsis

The effects of three doses of lorazepam (0.5, 1.0 and 2.0 mg PO) on various astxxzts of memory, attention and sedation are described. Lorazepam produced dose-related deficits in verbal secondary memory, choice reaction time and a novel vigilance task. It also produced a dosedependent increase in subjective sedation, and an enhancement of visual contrast sensitivity. These results are compared with those reported earlier using the musearinic antagonist scopolamine, and discussed in relation to models of Alzheimer's disease.

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