Effects of long-term hydration leading to the development of polar channels in hairless mouse stratum corneum
✍ Scribed by William J. Lambert; William I. Higuchi; Kristine Knutson; Steven L. Krill
- Book ID
- 102406137
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 403 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
Dramatic increases in in vitro permeability coefficients have been observed following the long-term hydration (days) of hairless mouse skin. The effect is greatest for extremely polar or ionized solutes. Differential scanning calorimetry has been utilized in complementary studies in an attempt to assess i i the altered permeability may be due to the irreversible alteration of lipid fluidity or keratin structure. The melting range of the lipid endotherms appears to be unaffected when stratum corneum is subjected to hydration conditions similar to those in the permeability experiments. Endotherms attributed to keratin appear to be