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Effects of liver failure on inter-organ trafficking of ammonia: implications for the treatment of hepatic encephalopathy

✍ Scribed by NICOLAS CHATAURET; ROGER F BUTTERWORTH


Book ID
108950071
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
101 KB
Volume
19
Category
Article
ISSN
0815-9319

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## Abstract Brain edema in acute hepatic encephalopathy (HE) is due mainly to swelling of astrocytes. Efflux of potassium is implicated in the prevention of glial swelling under hypoosmotic conditions. We investigated whether pathogenic factors of HE, glutamine (Gln) and/or ammonia, induce alterati