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Effects of lithium and amitriptyline therapy on somatosensory evoked response “excitability” measurements

✍ Scribed by Charles Shagass; John J. Straumanis; Donald A. Overton

Publisher
Springer
Year
1973
Tongue
English
Weight
638 KB
Volume
29
Category
Article
ISSN
0033-3158

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✦ Synopsis

Somatosensory responses obtained with a variety of stimulating conditions were measured in 14 patients before and during lithium carbonate therapy and in 12 patients treated with amitriptyline. Lithium increased evoked response amplitude, particularly in the early portion, and augmented the dynamic range of test responses following conditioning stimuli of different intensity; excitatory effects were enhanced more than inhibitory. Amitriptyline reduced response amplitude in both early and later portions, but did not affect dynamic range. The effects of amitriptyline were dominant over those of lithium in 3 patients treated with a combination of both drugs.

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## Abstract The effect on the somatosensory evoked response (SER) of the level of anesthesia, and the effect of the site, intensity, duration, and frequency of the stimulus on the amplitude and latency of various components of the SER were studied in 8 Rhesus monkeys. Peroneal nerve stimulation pro