✦ LIBER ✦

Effects of light exposure on the uptake of photofrin II in tumors and normal tissues

✍ Scribed by L. W. Ma; J. Moan; Q. Peng

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 461 KB
Volume: 52
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910520121

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

DBA mice bearing CaD~2~ mammary carcinomas were used to determine the effect of giving small doses of light to the tumor area 1.5 hr after injecting Photofrin II (PII). The smallest light dose applied (12.5 J/cm^2^) had no effect on the uptake of Pll in the tumor and its surrounding tissues, as measured 24 hr after the i.p. injection. However, several higher light doses increased the uptake of PII in the tumor significantly, the uptake in skin slightly, while the uptake in muscle tissue was decreased rather than increased. Thus, the PII concentration ratio between the tumor and the surrounding normal tissues was significantly improved. The rates of clearance of PII from irradiated tissues and non‐irradiated tissues were not significantly different. Most likely, the present observations are due to transient pH lowering in the tumor resulting from vascular damage. © 1992 Wiley‐Liss, Inc.

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