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Effects of lead(II) nitrate and a dithiocarbamate fungicide on the rat lung

✍ Scribed by Zoltán Adamis; Erzsébet Tátrai; Koichi Honma; György Ungváry

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
51 KB
Volume
19
Category
Article
ISSN
0260-437X

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✦ Synopsis

The pulmonary toxicity of two potential environmental pollutants was studied in rats 1, 7 and 30 days after a single intratracheal instillation of lead nitrate and Dithane M-45 (mancoceb), either individually or in various combinations. The cell count, protein, phospholipids and lactate dehydrogenase level were determined in the bronchoalveolar lavage fluid, as were the protein, phospholipids and acid phosphatase contents in the lung tissue. Lead nitrate and Dithane M-45 induced acute inflammation reactions with different features. The effects of mixtures of lead nitrate and Dithane M-45 were found to be different from those of the individual components.

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