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Effects of Large Neutral Amino Acid Concentrations on 6-[F-18]Fluoro-L-DOPA Kinetics

✍ Scribed by Stout, David B.; Huang, Sung-Cheng; Melega, William P.; Raleigh, Michael J.; Phelps, Michael E.; Barrio, Jorge R.


Book ID
110078854
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
574 KB
Volume
18
Category
Article
ISSN
0271-678X

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Positron tomography, using ['8F]6-fluoro-~-dopa as a tracer, has been used for the study of Parkinson's disease. Unfortunately, the analysis of data obtained with this agent is bedeviled because it readily forms labeled methylated metabolites that enter the brain. We have evaluated ['sF16-fluoro-L-m