Effects of Lamotrigine on Field Potentials and Long-Term Potentiation in Guinea Pig Hippocampal Slices
✍ Scribed by Jens Michael Langosch; Xiao-Yan Zhou; Alex Frick; Heinze Grunze; Jörg Walden
- Book ID
- 109108236
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2000
- Tongue
- English
- Weight
- 501 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0013-9580
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How adenosine leakage and tetanic release might affect long-term potentiation (LTP) was investigated by applying adenosine antagonists 8(p-sulfophenyl)theophylline (8SPT) or 8-cyclopentyl-3,7-dihydro-l,3-dipropyl-l H-purine-2,6-dione (DPCPX) to slices, while recording CA1 field EPSPs and population
## Abstract Lamotrigine (LTG) is an anti‐epileptic drug that is widely used clinically in various neuropsychiatric disorders. Although consensus is found on the general mode of action by LTG on voltage‐gated sodium current, its effect on field potential, neuropropagation, and long‐term potentiation