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Effects of ketoconazole on methylprednisolone pharmacokinetics and cortisol secretion

✍ Scribed by Glynn, Anne M; Slaughter, Richard L; Brass, Corstiaan; D'Ambrosio, Robin; Jusko, William J


Book ID
109843864
Publisher
Nature Publishing Group
Year
1986
Tongue
English
Weight
383 KB
Volume
39
Category
Article
ISSN
0009-9236

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✍ Tsutomu Kotegawa; Bart E. Laurijssens; Anna Liza B. Durol; David J. Greenblatt πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 114 KB πŸ‘ 2 views

To evaluate methodology for in vivo interaction studies of benzodiazepines (BZs) and ketoconazole (KCZ) in animal models, this study assessed the pharmacokinetics and electroencephalographic (EEG) effect of KCZ, and suitable dosage regimens of KCZ to maintain sufficiently high KCZ concentrations to