Effects of isopentenyl adenosine and phytohemagglutinin upon RNA syntheses in lymphocytes

✍ Scribed by Bruce Hacker; T. L. Feldbush

• Book ID: 101322978
• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 331 KB
• Volume: 27
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197106)27:6<1384::aid-cncr2820270618>3.0.co;2-f

✦ Synopsis

No-(Az-isopentenyl) adenosine (iPA) has been previously shown t o inhibit D N A and R N A synthesis in cultured lymphocytes and to suppress antibody formation i n vivo. The effects have been extended to show that iP.4 has little preferential action on phytohemagglutinin-transformed spleen cells i n vitro. Finally, iPA is found to alter the methylation of all species of RNA but in a disproportionate manner i n either PHA-transformed or non-stimulated lymphocytes.