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Effects of Iron Supplements on the Oral Bioavailability of Moxifloxacin, a Novel 8-Methoxyfluoroquinolone, in Humans

✍ Scribed by Dr Heino Stass, Dagmar Kubitza


Book ID
120803856
Publisher
Springer International Publishing AG
Year
2001
Tongue
English
Weight
129 KB
Volume
40
Category
Article
ISSN
0312-5963

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Sildenafil is the first oral therapeutic agent for the management of male erectile dysfunction. Its oral bioavailability is only 40% due to extensive presystemic elimination, mainly by CYP3A4. This study examined the effect of coadministration of ciprofloxacin or clarithromycin, which inhibit CYP3A4