Effects of Iron Overload and Lindane Intoxication in Relation to Oxidative Stress, Kupffer Cell Function, and Liver Injury in the Rat
β Scribed by Barbara Junge; Yasna Carrion; Cleofina Bosco; Monica Galleano; Susana Puntarulo; Gladys Tapia; Luis A. Videla
- Book ID
- 112267258
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 206 KB
- Volume
- 170
- Category
- Article
- ISSN
- 0041-008X
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Parameters related to oxidative stress in rat liver and erythrocytes were studied after shortterm administration (60 and 90 days) of 1000 ppm of lindane in the diet. Lindane induced an oxidative stress condition in the liver, which is related to an enhancement in microsomal NADPH-cytochrome c reduct
This study tested the hypothesis that acute iron overload (500 mg/kg) alters Kupffer cell functioning by promoting free radical reactions associated with the respiratory burst of liver macrophages, assessed in the isolated perfused rat liver under conditions of Kupffer cell stimulation by carbon inf