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Effects of iprindole on levels of enantiomers of fluoxetine and nor-fluoxetine in rat brain

✍ Scribed by Aspeslet, L.J.; Torok-Both, G.; Baker, G.B.; Coutts, R.T.

Book ID
123498923
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
106 KB
Volume
21
Category
Article
ISSN
0197-0186

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The effects of desipramine and iprindole
The effects of desipramine and iprindole on levels of enantiomers of fluoxetine in rat brain and urine
✍ Launa J. Aspeslet; Glen B. Baker; Ronald T. Coutts; George A. Torok-Both πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 533 KB

The antidepressant fluoxetine (FLU) and its N-demethylated metabolite, norfluoxetine (NFLU), each contains a chiral center. The combination of FLU and desipramine (DMI), another antidepressant, has been reported to be useful in treatment of depression, to dramatically increase plasma levels of DMI a